A characteristic feature of aged humans and other mammals is the debilitating, progressive
loss of skeletal muscle function and mass that is known as sarcopenia. Age-related muscle …

The fruit fly, Drosophila melanogaster, has a long and rich history as an important model
organism for biologists. In particular, study of the fruit fly has been essential to much of our …

Duchenne muscular dystrophy is caused by mutations in the dystrophin gene and is
characterized by progressive muscle wasting. A number of Duchenne patients also present …

Neurexins have been proposed to function as major mediators of the coordinated pre-and
postsynaptic apposition. However, key evidence for this role in vivo has been lacking …

Since its first description in 1990, the dystrophin–glycoprotein complex has emerged as a
critical nexus for human muscular dystrophies arising from defects in a variety of distinct …

Duchenne muscular dystrophy (DMD) is a progressive muscle-wasting disease. Recently
approved molecular/gene treatments do not solve the downstream inflammation-linked …

Transcription factors specify the fate and connectivity of developing neurons. We investigate
how a lineage-specific transcription factor, Acj6, controls the precise dendrite targeting of …

Dystroglycan is a cell membrane protein that binds to the extracellular matrix in a variety of
mammalian tissues. The α-subunit of dystroglycan (αDG) is heavily glycosylated, including a …

The fruit fly Drosophila melanogaster has emerged as a useful model for cardiac diseases,
both developmental abnormalities and adult functional impairment. Using the tools of both …

The Dystrophin-Associated Protein Complex (DAPC) is a well-defined and evolutionarily
conserved complex in animals. DAPC interacts with the F-actin cytoskeleton via dystrophin …