During animal fertilizations, each oocyte or egg must produce a proper intracellular calcium
signal for development to proceed normally. As a supplement to recent synopses of …

At fertilization in mammals, the sperm activates development by causing a prolonged series
of intracellular Ca2+ oscillations that are generated by increased production of inositol …

Publisher Summary At fertilization in mammals, the incoming sperm makes two essential
contributions to the development of the new organism. One contribution is the DNA and all …

Reviews in Developmental Biology have covered the pathways that generate the all-
important intracellular calcium (Ca2+) signal at fertilization [Miyazaki, S., Shirakawa, H …

Publisher Summary The chapter discusses signal transduction mechanisms in the activation
of mammalian eggs, primarily in the mouse, and explains the sequence of events that …

Fertilization of the immature, prophase I-arrested mouse oocyte produces multiple Ca2+
transients similar to those of the mature, metaphase II egg; however, the first Ca2+ transient …

In this study we evaluated nuclear and ooplasmic maturation of prepuberal calf oocytes to
determine a possible cause for their low developmental competency. Calf oocytes resumed …

Fertilization in all species studied to date induces an increase in the intracellular
concentration of free calcium ions ([Ca2+] i) within the egg. In mammals, this [Ca2+] i signal …

Abbreviations used in this paper: BrdU, 5-bromo-2-deoxyuridine; Ca2+, calcium; cdk, cyclin-
dependent kinase; CDKI, cdk inhibitor; CSF, cytostatic factor; G protein, GTP binding protein; …

Our previous studies have shown that oocytes collected from prepubertal calves lack
developmental competence. The overall objective of this study was to assess causes by …