The majority of severe clinically significant forms of congenital heart disease (CHD) are
associated with great artery lesions, including hypoplastic, double, right or interrupted aortic …

Significant progress has been made in neonatal cardiopulmonary bypass (CPB) over the
years. At Penn State Health Children's Hospital, we have established a multidisciplinary …

Translational research is a useful tool to provide scientific evidence for cannula selection
during extracorporeal life support (ECLS). The objective of this study was to evaluate four …

The pathology of the human abdominal aortic aneurysm (AAA) and its relationship to the
later complication of intraluminal thrombus (ILT) formation remains unclear. The …

Background Peripheral ECMO is an effective cardiopulmonary support in clinical. The
perfusion level could directly influence the performances and complications. However, there …

Cannulation strategies in medical treatment such as in extracorporeal life support along with
the associated cannula position, orientation and design, affects the mixing and the …

Poor perfusion of the aortic arch is a suspected cause for peri-and post-operative
neurological complications associated with cardiopulmonary bypass (CPB). High-speed jets …

Background Pediatric cardiomyopathies are a rare, yet heterogeneous group of pathologies
of the myocardium that are routinely examined clinically using Cardiovascular Magnetic …

In this study, hemodynamic performance of three novel shunt configurations that are
considered for the surgical repair of tetralogy of Fallot (TOF) disease are investigated in …

Transitional and turbulent flow through a simplified medical device model is analyzed as
part of the FDA's Critical Path Initiative, designed to improve the process of bringing medical …