Cerebral blood flow decrease as an early pathological mechanism in Alzheimer's disease
Therapies targeting late events in Alzheimer's disease (AD), including aggregation of
amyloid beta (Aβ) and hyperphosphorylated tau, have largely failed, probably because they …
amyloid beta (Aβ) and hyperphosphorylated tau, have largely failed, probably because they …
Benzimidazoles in drug discovery: a patent review
Benzimidazole is a heterocyclic ring system that has been widely studied in the
pharmaceutical field. For the past decade, numerous benzimidazole derivatives have been …
pharmaceutical field. For the past decade, numerous benzimidazole derivatives have been …
Advances in the discovery of heterocyclic-based drugs against Alzheimer's disease
Introduction Alzheimer's disease is a multifactorial neurodegenerative disorder
characterized by beta-amyloid accumulation and tau protein hyperphosphorylation. The …
characterized by beta-amyloid accumulation and tau protein hyperphosphorylation. The …
Association study between drug prescriptions and Alzheimer's disease claims in a commercial insurance database
In the ongoing effort to discover treatments for Alzheimer's disease (AD), there has been
considerable focus on investigating the use of repurposed drug candidates. Mining of …
considerable focus on investigating the use of repurposed drug candidates. Mining of …
Targeting neuronal calcium channels and GSK3β for Alzheimer's disease with naturally-inspired Diels-Alder adducts
A Bisi, A Feoli, A Trezza, L Viejo, F Formaggio… - Bioorganic …, 2022 - Elsevier
The complexity of neurodegenerative diseases, among which Alzheimer's disease plays a
pivotal role, poses one of the tough therapeutic challenges of present time. In this …
pivotal role, poses one of the tough therapeutic challenges of present time. In this …
Associations among hypertension, dementia biomarkers, and cognition: The MEMENTO cohort
J Lespinasse, G Chêne, J Mangin… - Alzheimer's & …, 2023 - Wiley Online Library
Introduction Approximately 40% of dementia cases could be delayed or prevented acting on
modifiable risk factors including hypertension. However, the mechanisms underlying the …
modifiable risk factors including hypertension. However, the mechanisms underlying the …
Fenoterol and dobutamine as SARS-CoV-2 main protease inhibitors: A virtual screening study
Global health is under heavy threat by a worldwide pandemic caused by a new type of
coronavirus (COVID-19) since its rapid spread in China in 2019 [1]. Currently, there are no …
coronavirus (COVID-19) since its rapid spread in China in 2019 [1]. Currently, there are no …
New insights into repurposing of renin-angiotensin system inhibitors against Alzheimer's disease
S Mishra, S Pattanaik, S Sahoo, SK Prusty… - Journal of Applied …, 2024 - japsonline.com
Alzheimer's disease (AD) is a progressive neurodegenerative disorder characterized by a
complex and multidimensional pathology, including amyloid-β plaques …
complex and multidimensional pathology, including amyloid-β plaques …
Carvedilol protects against Cognitive Dysfunction Through Inhibition of Amyloid Beta (1-42) and Inflammation in Aluminum Chloride Induced Alzheimer's Disease …
S Ahmed, M Nasry, W Mohammed - Records of Pharmaceutical and …, 2022 - journals.ekb.eg
The current study aimed to assess and compare the preventive effects of carvedilol (CAR)
and donepezil (DONP) on aluminum chloride (AlCl3)-induced Alzheimer's Disease (AD). A …
and donepezil (DONP) on aluminum chloride (AlCl3)-induced Alzheimer's Disease (AD). A …
Computational biology approaches for drug repurposing.
T Waseem, TA Rajput, MS Mushtaq… - Progress in Molecular …, 2024 - europepmc.org
The drug discovery and development (DDD) process greatly relies on the data available in
various forms to generate hypotheses for novel drug design. The complex and …
various forms to generate hypotheses for novel drug design. The complex and …