abstract The blood-brain barrier (BBB) is a highly complex and dynamic barrier. It is formed
by an interdependent network of brain capillary endothelial cells, endowed with barrier …

Connexins, a family of transmembrane proteins, are components of both gap junction
channels and hemichannels, which mediate the exchange of ions and small molecules …

Cellular communication mediated by gap junction channels and hemichannels, both
composed of connexin proteins, constitutes two acknowledged regulatory platforms in the …

We have previously demonstrated that systemic AMP-activated protein kinase α1 (AMPKα1)
invalidation enhanced adverse LV remodelling by increasing fibroblast proliferation, while …

Barrier function is a vital homeostatic mechanism employed by epithelial and endothelial
tissue. Diseases across a wide range of tissue types involve dynamic changes in …

Abstract Connexin43 (Cx43) is a ubiquitously expressed member of the gap junction protein
family that mediates gap junction intercellular communication (GJIC) by allowing exchange …

Background: Postliver transplantation acute kidney injury (AKI) severely affects patient
survival, whereas the mechanism is unclear and effective therapy is lacking. The authors …

It is nowadays well established that gap junctions are critical gatekeepers of cell
proliferation, by controlling the intercellular exchange of essential growth regulators. In …

Mounting evidence indicates that dysregulation of gap junctions and their structural subunits—
connexins—often occurs in, and sometimes causes, a variety of proliferative disorders …

Previous work showed that connexin 43 (Cx43) reduced the expression of hypoxic-induced
factor-1α (HIF-1α) in astrocytes. HIF-1α is a master transcription factor for angiogenesis in …