The past decade has seen impressive advances in understanding the biosynthesis of
ribosomally synthesized and posttranslationally modified peptides (RiPPs). One of the most …

Covering: 2000 to up to 2023 α, β-Dehydroamino acids (dhAAs) are unsaturated
nonproteinogenic amino acids found in a wide array of naturally occurring peptidyl …

Lanthipeptides are a class of cyclic peptides characterized by the presence of one or more
lanthionine (Lan) or methyllanthionine (MeLan) thioether rings. These cross-links are …

Lanthipeptides are ribosomally synthesized and post-translationally modified peptides
characterized by lanthionine (Lan) and/or methyllanthionine (MeLan) residues. Four classes …

LanD flavoproteins catalyze oxidative decarboxylation of the C‐terminal Cys residue of a
peptide to produce an enethiol. This enethiol is highly reactive and can be coupled with an …

Thioholgamides are ribosomally synthesized and posttranslationally modified peptides
(RiPPs), with potent activity against cancerous cell lines and an unprecedented structure …

Natural products that contain distinctive chemical functionality can serve as useful starting
points to develop Nature's compounds into viable therapeutics. Peptide natural products, an …

Linaridins and lanthipeptides are two classes of natural products belonging to the
ribosomally synthesized and posttranslationally modified peptide (RiPP) superfamily …

Thioaldehyde is a highly electrophilic group under aqueous conditions and can be
generated via oxidative enzymatic modifications of cysteine residues in peptides and …

L-Cysteine is a highly reactive amino acid that is modified into a variety of chemical
structures, including cysteine sulfinic acid in human metabolic pathways, and sulfur …