Parathyroid hormone–related protein was identified in the 1980s as a tumor product that had
the ability to activate parathyroid hormone receptors and cause hypercalcemia. 1 …

Although parathyroid hormone-related protein (PTHrP) was discovered as a cancer-derived
hormone, it has been revealed as an important paracrine/autocrine regulator in many …

Pathophysiological mechanisms of vascular calcification in end-stage renal disease.
Vascular calcification has been clearly defined as a risk factor for cardiovascular mortality in …

Parathyroid hormone (PTH) has a central role in the regulation of serum calcium and
phosphate, while parathyroid hormone-related peptide (PTHrP) has important …

Macromolecules and supramolecular complexes are frequently required to enter and exit
the nucleus during normal cell function, but access is restricted and exchange to and from …

Nuclear import of proteins containing a classical nuclear localization signal (NLS) involves
NLS recognition by importin α, which associates with importin β via the IBB domain. Other …

The cloning of the so‐called 'parathyroid hormone‐related protein'(PTHrP) in 1987 was the
result of a long quest for the factor which, by mimicking the actions of PTH in bone and …

The majority of men with progressive prostate cancer develop metastases with the skeleton
being the most prevalent metastatic site. Unlike many other tumors that metastasize to bone …

Parathyroid hormone-related protein (PTHrP), expressed in a range of tumors, has
endocrine, autocrine/paracrine, and intracrine actions, some of which relate to its ability to …

Prior reports have demonstrated that both parathyroid hormone-related protein (PTHrP) and
the type I PTH/PTHrP receptor are necessary for the proper development of the embryonic …