Towards network-guided neuromodulation for epilepsy

RJ Piper, RM Richardson, G Worrell, DW Carmichael… - Brain, 2022 - academic.oup.com
Epilepsy is well-recognized as a disorder of brain networks. There is a growing body of
research to identify critical nodes within dynamic epileptic networks with the aim to target …

Neurobehavioural comorbidities of epilepsy: towards a network-based precision taxonomy

BP Hermann, AF Struck, RM Busch, A Reyes… - Nature Reviews …, 2021 - nature.com
Cognitive and behavioural comorbidities are prevalent in childhood and adult epilepsies
and impose a substantial human and economic burden. Over the past century, the classic …

Regional and global connectivity disturbances in focal epilepsy, related neurocognitive sequelae, and potential mechanistic underpinnings

DJ Englot, PE Konrad, VL Morgan - Epilepsia, 2016 - Wiley Online Library
Epilepsy is among the most common brain network disorders, and it is associated with
substantial morbidity and increased mortality. Although focal epilepsy was traditionally …

Association of piriform cortex resection with surgical outcomes in patients with temporal lobe epilepsy

M Galovic, I Baudracco, E Wright-Goff, G Pillajo… - JAMA …, 2019 - jamanetwork.com
Importance A functional area associated with the piriform cortex, termedarea tempestas, has
been implicated in animal studies as having a crucial role in modulating seizures, but similar …

Multimodal MRI profiling of focal cortical dysplasia type II

SJ Hong, BC Bernhardt, B Caldairou, JA Hall… - Neurology, 2017 - AAN Enterprises
Objective: To characterize in vivo MRI signatures of focal cortical dysplasia (FCD) type IIA
and type IIB through combined analysis of morphology, intensity, microstructure, and …

A scoping review of the functional magnetic resonance imaging‐based functional connectivity of focal cortical dysplasia‐related epilepsy

NT Cohen, H Xie, T Gholipour, WD Gaillard - Epilepsia, 2023 - Wiley Online Library
Focal cortical dysplasia (FCD) is the most frequent etiology of operable pharmacoresistant
epilepsy in children. There is burgeoning evidence that FCD‐related epilepsy is a disorder …

[PDF][PDF] Pivotal role of subcortical structures as a network hub in focal epilepsy: evidence from graph theoretical analysis based on diffusion-tensor imaging

KM Park, BI Lee, KJ Shin, SY Ha… - Journal of Clinical …, 2019 - synapse.koreamed.org
Background and Purpose There is accumulating evidence that epilepsy is caused by
network dysfunction. We evaluated the hub reorganization of subcortical structures in …

[HTML][HTML] The dynamics of functional connectivity in neocortical focal epilepsy

M Pedersen, A Omidvarnia, EK Curwood, JM Walz… - NeuroImage: Clinical, 2017 - Elsevier
Focal epilepsy is characterised by paroxysmal events, reflecting changes in underlying local
brain networks. To capture brain network activity at the maximal temporal resolution of the …

Disruption of functional connectivity among subcortical arousal system and cortical networks in temporal lobe epilepsy

R Li, C Hu, L Wang, D Liu, D Liu, W Liao, B Xiao… - Brain Imaging and …, 2020 - Springer
Growing evidence has demonstrated widespread brain network alterations in temporal lobe
epilepsy (TLE). However, the relatively accurate portrait of the subcortical-cortical …

Neuroimaging and thalamic connectomics in epilepsy neuromodulation

EH Middlebrooks, X He, SS Grewal, SS Keller - Epilepsy Research, 2022 - Elsevier
Neuromodulation is an increasingly utilized therapy for the treatment of people with drug-
resistant epilepsy. To date, the most common and effective target has been the thalamus …