Autophagy is a fundamental cellular process that eliminates molecules and subcellular
elements, including nucleic acids, proteins, lipids and organelles, via lysosome-mediated …

Macroautophagy (hereafter called autophagy) is a highly conserved physiological process
that degrades over-abundant or damaged organelles, large protein aggregates and …

Cathepsins are the most abundant lysosomal proteases that are mainly found in acidic
endo/lysosomal compartments where they play a vital role in intracellular protein …

Autophagic pathways cross with lipid homeostasis and thus provide energy and essential
building blocks that are indispensable for liver functions. Energy deficiencies are …

The ageing process is a systemic decline from cellular dysfunction to organ degeneration,
with more predisposition to deteriorated disorders. Rejuvenation refers to giving aged cells …

The AMP-activated protein kinase (AMPK) is a central regulator of multiple metabolic
pathways and may have therapeutic importance for treating obesity, insulin resistance, type …

Cancer cells possess remarkable abilities to adapt to adverse environmental conditions.
Their survival during severe nutrient and oxidative stress depends on their capacity to …

Lysosomes are the main proteolytic compartments of mammalian cells comprising of a
battery of hydrolases. Lysosomes dispose and recycle extracellular or intracellular …

Cyclodextrins are among the most remarkable macrocyclic molecules with significant
theoretical and practical impacts in chemistry and biology. Cyclodextrins belong to the family …

Our understanding of the process of autophagy and its role in health and diseases has
grown remarkably in the last two decades. Early work established autophagy as a general …