Cytokinesis is the final stage of cell division during which the two daughter cells separate
completely. Although less well understood than some of the earlier phases of the cell cycle …

INTRODUCTION In response to aging, senescence plays a major role in the onset of various
degenerative diseases, including the slow development of cataracts, a clouding of the eye …

Axons are the narrow, up-to-meter long cellular processes of neurons that form the
biological cables wiring our nervous system. Most axons must survive for an organism's …

Microtubules are dynamic cytoskeletal elements coordinating and supporting a variety of
neuronal processes, including cell division, migration, polarity, intracellular trafficking, and …

Cytokinesis and abscission are complicated events that involve changes in membrane
transport and cytoskeleton organization. We have used the combination of time-lapse …

Colchicine has been used to treat gout and, more recently, to effectively prevent
autoinflammatory diseases and both primary and recurrent episodes of pericarditis. The anti …

The tubulin heterodimer consists of one α-and one β-tubulin polypeptide. Neither protein
can partition to the native state or assemble into polymerization competent heterodimers …

Microtubule dynamics involves the polymerization and depolymerization of tubulin dimers
and is an essential and highly regulated process required for cell viability, architecture, and …

Assembly of the α/β tubulin heterodimer requires the participation of a series of chaperone
proteins (TBCA‐E) that function downstream of the cytosolic chaperonin (CCT) as a …

Mutation in a growing spectrum of genes is known to either cause or contribute to primary or
secondary microcephaly. In primary microcephaly the genetic determinants frequently …