The concept of a scaffold concerns many aspects at different steps on the drug development
path. In medicinal chemistry, the choice of relevant “drug-likeness” scaffold is a starting point …

It is over 50 years since the discovery of microtubules, and they have become one of the
most important drug targets for anti-cancer therapies. Microtubules are predominantly …

Combretastatins are a class of closely related stilbenes (combretastatins A),
dihydrostilbenes (combretastatins B), phenanthrenes (combretastatins C) and macrocyclic …

Microtubules are cylindrical protein polymers formed from α β-tubulin heterodimers in the
cytoplasm of eukaryotic cells. Microtubule disturbance may cause cell cycle arrest in the …

Piperazine moiety is a cyclic molecule containing two nitrogen atoms in positions 1 and 4, as
well as four carbon atoms. Piperazine is one of the most sought heterocyclics for the …

In the design of polymeric biomaterials for soft tissue adhesion, careful regulation of the
interactions between the material and soft tissue is critical. In order to improve the efficacy of …

The synthesis and biochemical activity of a series of chiral trans 3-hydroxyl β-lactams
targeting tubulin is described. Synthesis of the series of enantiopure β-lactams was …

Through the exploitation of several conventional strategies in subdisciplines of chemistry
and the molecular sciences became challenging due to toxic chemicals in last few years. As …

Among all cancer types, breast cancer (BC) still stands as one of the most serious diseases
responsible for a large number of cancer-associated deaths among women worldwide, and …

Antimitotic drugs that target tubulin are among the most widely used chemotherapeutic
agents; however, the development of multidrug resistance has limited their clinical activity …