Immunotherapy, specifically the introduction of immune checkpoint inhibitors, has
transformed the treatment of cancer, enabling long-term tumour control even in individuals …

The use of existing mouse models in cancer research is of utmost importance as they aim to
explore the casual link between candidate cancer genes and carcinogenesis as well as to …

Cancer is a major stress for public well‐being and is the most dreadful disease. The models
used in the discovery of cancer treatment are continuously changing and extending toward …

While much progress has been made in the war on cancer, highly invasive cancers such as
pancreatic cancer remain difficult to treat and anti-cancer clinical trial success rates remain …

Precision medicine aims to use patient genomic, epigenomic, specific drug dose, and other
data to define disease patterns that may potentially lead to an improved treatment outcome …

Cancer therapeutics have undergone immense research over the past decade. While
chemotherapies remain the mainstay treatments for many cancers, the advent of new …

There is inherent tension between methodologies developed to address basic research
questions in model species and those intended for preclinical to clinical translation: basic …

A major barrier to successful pancreatic cancer (PC) treatment is the surrounding stroma,
which secretes growth factors/cytokines that promote PC progression. Wnt and tenascin C …

Digital twins in precision medicine provide tailored health recommendations by simulating
patient-specific trajectories and interventions. We examine the critical role of Verification …

Recent advances in cancer biology and therapeutics have underscored the importance of
preclinical models in understanding and treating cancer. Nevertheless, current models often …