Abstract Familial Mediterranean fever (FMF)(OMIM# 249100) is the most common hereditary
autoinflammatory disease in the world. FMF is caused by gain of function mutations of MEFV …

Kidney injury implies danger signaling and a response by the immune system. The
inflammasome is a central danger recognition platform that triggers local and systemic …

Familial Mediterranean fever (FMF) is the most common monogenic autoinflammatory
disease (AID) affecting mainly the ethnic groups originating from Mediterranean basin. The …

Familial Mediterranean fever (FMF) is the most common monogenic periodic fever syndrome
and characterized by recurrent episodes of fever, serositis, arthritis, dermal manifestations …

Objective Familial Mediterranean fever (FMF) is refractory to colchicine prophylaxis in 10–
20% of patients. In a number of patient series, treatment with anakinra, an interleukin‐1 …

Amyloid A amyloidosis is thought to be the second most common form of systemic
amyloidosis behind amyloidosis secondary to monoclonal Ig. It is the result of deposition of …

Dysregulation of the interleukin-1 (IL-1) pathway leads to immune diseases that can result in
chronic tissue and organ inflammation. Although IL-1 blockade has shown promise in …

Autoinflammatory diseases (AIDs) represent a rare and heterogeneous group of disorders
characterized by recurrent episodes of inflammation and a broad range of clinical …

Background Despite their limited licensed indications, anti–interleukin-1 (anti–IL-1) agents
are often used in clinical practice for an increasing number of auto-inflammatory diseases …

Introduction In 5%–10% of patients with familial Mediterranean fever (FMF), colchicine is not
effective in preventing inflammatory attacks. Another 5%–10% of patients are intolerant to …