Current and emerging therapies for limbal stem cell deficiency

AM Elhusseiny, M Soleimani, TK Eleiwa… - Stem cells …, 2022 - academic.oup.com
The corneal epithelium serves to protect the underlying cornea from the external
environment and is essential for corneal transparency and optimal visual function …

Strategies for reconstructing the limbal stem cell niche

G Yazdanpanah, Z Haq, K Kang, S Jabbehdari… - The ocular …, 2019 - Elsevier
The epithelial cell layer that covers the surface of the cornea provides a protective barrier
while maintaining corneal transparency. The rapid and effective turnover of these epithelial …

Angiogenesis and lymphangiogenesis in corneal transplantation–A review

W Zhong, M Montana, SM Santosa, ID Isjwara… - Survey of …, 2018 - Elsevier
Corneal transplantation has been proven effective for returning the gift of sight to those
affected by corneal disorders such as opacity, injury, and infections that are a leading cause …

Cornea-derived mesenchymal stromal cells therapeutically modulate macrophage immunophenotype and angiogenic function

M Eslani, I Putra, X Shen, J Hamouie, A Tadepalli… - Stem Cells, 2018 - academic.oup.com
Macrophages are crucial drivers of inflammatory corneal neovascularization and thus are
potential targets for immunomodulatory therapies. We hypothesized that therapeutic use of …

Lymphangiogenesis and lymphatic barrier dysfunction in renal fibrosis

J Liu, C Yu - International Journal of Molecular Sciences, 2022 - mdpi.com
As an integral part of the vascular system, the lymphatic vasculature is essential for tissue
fluid homeostasis, nutritional lipid assimilation and immune regulation. The composition of …

Application of corneal injury models in dual fluorescent reporter transgenic mice to understand the roles of the cornea and limbus in angiogenic and lymphangiogenic …

X Gao, K Guo, SM Santosa, M Montana… - Scientific reports, 2019 - nature.com
The role of the corneal epithelium and limbus in corneal avascularity and pathological
neovascularization (NV) is not well understood. To investigate the contributions of the …

Fluorescent reporter transgenic mice for in vivo live imaging of angiogenesis and lymphangiogenesis

SJ Doh, M Yamakawa, SM Santosa, M Montana, K Guo… - Angiogenesis, 2018 - Springer
The study of lymphangiogenesis is an emerging science that has revealed the lymphatic
system as a central player in many pathological conditions including cancer metastasis …

Emerging approaches for ocular surface regeneration

G Yazdanpanah, S Jabbehdari, AR Djalilian - Current ophthalmology …, 2019 - Springer
Abstract Purpose of Review In this manuscript, the recent advancements and novel
approaches for regeneration of the ocular surface are summarized. Recent Findings …

Simultaneous fluorescence imaging of distinct nerve and blood vessel patterns in dual Thy1-YFP and Flt1-DsRed transgenic mice

SM Santosa, K Guo, M Yamakawa, E Ivakhnitskaia… - Angiogenesis, 2020 - Springer
Blood vessels and nerve tissues are critical to the development and functionality of many
vital organs. However, little is currently known about their interdependency during …

Quantification of angiogenesis and lymphangiogenesis in the dual ex vivo aortic and thoracic duct assay

S Wang, M Yamakawa, SM Santosa… - Protein and peptide …, 2020 - ingentaconnect.com
Background: Lymphatic vessel formation (lymphangiogenesis) plays important roles in
cancer metastasis, organ rejection, and lymphedema, but the underlying molecular events …