Strategies of polymeric nanoparticles for enhanced internalization in cancer therapy

L Sun, Q Wu, F Peng, L Liu, C Gong - Colloids and Surfaces B …, 2015 - Elsevier
In order to achieve long circulation time and high drug accumulation in the tumor sites via
the EPR effects, anticancer drugs have to be protected by non-fouling polymers such as poly …

In vivo phage display—a discovery tool in molecular biomedicine

J Bábíčková, Ľ Tóthová, P Boor, P Celec - Biotechnology advances, 2013 - Elsevier
In vivo phage display is a high-throughput method for identifying target ligands specific for
different vascular beds. Targeting is possible due to the heterogeneous expression of …

Glioma-targeted therapy using Cilengitide nanoparticles combined with UTMD enhanced delivery

YZ Zhao, Q Lin, HL Wong, XT Shen, W Yang… - Journal of controlled …, 2016 - Elsevier
Malignant gliomas especially glioblastoma (GBM) are poorly responsive to the current
treatments. Cilengitide (CGT) is a cyclic pentapeptide that demonstrated efficacy for GBM …

Antitumor activity of thermosensitive hydrogels packaging gambogic acid nanoparticles and tumor-penetrating peptide iRGD against gastric cancer

D Zhang, Y Chu, H Qian, L Qian, J Shao… - International journal …, 2020 - Taylor & Francis
Introduction Gambogic acid (GA) is proved to have anti-tumor effects on gastric cancer. Due
to poor solubility, non-specific biological distribution, toxicity to normal tissues and short half …

Core-shell nanocarriers with high paclitaxel loading for passive and active targeting

Z Jin, Y Lv, H Cao, J Yao, J Zhou, W He, L Yin - Scientific Reports, 2016 - nature.com
Rapid blood clearance and premature burst release are inherent drawbacks of conventional
nanoparticles, resulting in poor tumor selectivity. iRGD peptide is widely recognized as an …

Development of a Squaraine-Based Molecular Probe for Dual-Modal in Vivo Fluorescence and Photoacoustic Imaging

YD Park, JE Park, HS Kim, SH Choi, JE Park… - Bioconjugate …, 2020 - ACS Publications
Dual-modular imaging approaches combining near-infrared (NIR) fluorescence (FLI) and
photoacoustic imaging (PAI) require suitable contrast agents to produce dual-modular …

Increased preosteoblast adhesion and osteogenic gene expression on TiO2 nanotubes modified with KRSR

SJ Sun, WQ Yu, YL Zhang, FQ Zhang - Journal of Materials Science …, 2013 - Springer
TiO 2 anodized nanotubelayers are potentially useful for orthopedic and dental implants
because they promotes bone formation. Peptide sequences, such as lysine-arginine-serine …

Pep-1 peptide-functionalized liposome to enhance the anticancer efficacy of cilengitide in glioma treatment

Z Jiao, Y Li, H Pang, Y Zheng, Y Zhao - Colloids and Surfaces B …, 2017 - Elsevier
In this study, we have established an effective and novel nanocarrier system for the effective
treatment of glioma. We have established the glioma tissue penetrating nanocarrier system …

Sheltering DNA in self-organizing, protein-only nano-shells as artificial viruses for gene delivery

U Unzueta, P Saccardo, J Domingo-Espin… - … , Biology and Medicine, 2014 - Elsevier
By recruiting functional domains supporting DNA condensation, cell binding, internalization,
endosomal escape and nuclear transport, modular single-chain polypeptides can be …

Vascular-homing peptides for targeted drug delivery and molecular imaging: meeting the clinical challenges

N D'Onofrio, M Caraglia, A Grimaldi, R Marfella… - … et Biophysica Acta (BBA …, 2014 - Elsevier
The vasculature of each organ expresses distinct molecular signatures critically influenced
by the pathological status. The heterogeneous profile of the vascular beds has been …