KRAS is one of the most frequently mutated oncogenes in cancer, being a potent initiator of
tumorigenesis, a strong inductor of malignancy, and a predictive biomarker of response to …

Lung cancer is one of the most common diseases worldwide today and has the highest
mortality rate among cancers. Therefore, early diagnosis of this disease is of special …

Lung cancer is nowadays among the most prevalent diseases worldwide and features the
highest mortality rate among various cancers, indicating that early diagnosis of the disease …

Purpose The safety and efficacy of pembrolizumab, a humanized monoclonal antibody
against programmed death 1 (PD-1), were assessed in patients with programmed death …

Activation of the EGFR, KRAS, and ALK oncogenes defines 3 different pathways of
molecular pathogenesis in lung adenocarcinoma. However, many tumors lack activation of …

Background Lung adenocarcinomas (LUAD) is the most common histological subtype of
lung cancers. Tumor immune microenvironment (TIME) is involved in tumorigeneses …

In the last decades the approach to cancer patient management has been deeply
revolutionized. We are moving from a “one-fits-all” strategy to the “personalized medicine” …

Lipids, particularly phospholipids (PLs), are key components of cellular membrane. PLs play
important and diverse roles in cells such as chemical‐energy storage, cellular signaling, cell …

Purpose This randomized, open-label trial compared dacomitinib (PF-00299804), an
irreversible inhibitor of human epidermal growth factor receptors (EGFR)/HER1, HER2, and …

Mucinous ovarian carcinomas (MCs) typically do not respond to current conventional
therapy. We have previously demonstrated amplification of HER2 in 6 of 33 (18.2%) …