VRK1 is a nuclear Ser-Thr chromatin kinase that does not mutate in cancer, and is
overexpressed in many types of tumors and associated with a poor prognosis. Chromatin …

Distal hereditary neuropathies and neuro motor diseases are complex neurological
phenotypes associated with pathogenic variants in a large number of genes, but in some the …

Glucose metabolism and DNA repair are fundamental cellular processes frequently
dysregulated in cancer. In this study, we define a direct role for the glycolytic Aldolase A …

The accessibility of DNA to different cellular functions requires a dynamic regulation of
chromatin organization that is mediated by different epigenetic modifications, which regulate …

Drug resistance to platinum chemotherapeutics targeting DNA often involves abrogation of
apoptosis and has emerged as a significant challenge in modern, non-targeted …

A key role of chromatin kinases is to phosphorylate histone tails during mitosis to
spatiotemporally regulate cell division. Vaccinia-related kinase 1 (VRK1) is a serine …

Barrier-to-autointegration factor (BAF; encoded by BANF1) is a small highly conserved,
ubiquitous and self-associating protein that coordinates with numerous binding partners to …

Dynamic chromatin remodeling requires regulatory mechanisms for its adaptation to
different nuclear function, which are likely to be mediated by signaling proteins. In this …

Simple Summary Dynamic remodeling of chromatin requires epigenetic modifications of
histones. DNA damage induced by doxorubicin causes an increase in histone H4K16ac, a …

Background Dynamic chromatin remodeling is associated with changes in the epigenetic
pattern of histone acetylations and methylations required for processes based on dynamic …