Perturbation of mitochondrial function can trigger a host of cellular responses that seek to
restore cellular metabolism, cytosolic proteostasis, and redox homeostasis. In some cases …

Caloric restriction and intermittent fasting prolong the lifespan and healthspan of model
organisms and improve human health. The natural polyamine spermidine has been similarly …

Alzheimer's disease (AD) is a highly prevalent neurodegenerative condition that has
devastating effects on individuals, often resulting in dementia. AD is primarily defined by the …

Ancient humans used dietary plants and herbs to treat disease and to pursue eternal life.
Today, phytochemicals in dietary plants and herbs have been shown to be the active …

Coffee is one of the most consumed beverages worldwide, recognized for its unique taste
and aroma and for its social and health impacts. Coffee contains a plethora of nutritional and …

The eight biological hallmarks of health that we initially postulated (Cell. 2021 Jan 7; 184 (1):
33-63) include features of spatial compartmentalization (integrity of barriers, containment of …

Although several antidepressants have been identified as potential geroprotectors, the effect
and mechanism of fluoxetine, a representative selective serotonin reuptake inhibitor, on …

The natural aging process is accompanied by changes in exosomes, gut microbiota, and
metabolites. This study aimed to reveal the anti-aging effect and mechanisms of fecal …

β-Carbolines (βCs) are bioactive indole alkaloids found in foods and in vivo. This work
describes the identification, formation, and occurrence in foods of the βC with a furan moiety …

Background Type 2 diabetes mellitus (T2DM) is primarily attributed to impaired insulin
secretion caused by β cell dysfunction. 1, 8-Cineole is a key bioactive compound in the …