The development of novel neuropharmaceuticals requires the evaluation of blood–brain
barrier (BBB) permeability and toxicity. Recent studies have highlighted differences in the …

Nucleoside analogs are important components of treatment regimens for various
malignancies. Nucleoside-specific membrane transporters mediate plasma membrane …

J. Neurochem.(2011) 117, 333–345. Abstract We have obtained, for the first time, a
quantitative protein expression profile of membrane transporters and receptors in human …

Concentrative nucleoside transporters (CNT; SLC28) and equilibrative nucleoside
transporters (ENT; SLC29) mediate the uptake of natural nucleosides and a variety of …

Nucleoside and nucleobase analogs are currently used in the treatment of solid tumors,
lymphoproliferative diseases, viral infections such as hepatitis and AIDS, and some …

The outcomes in children with refractory/relapsed (R/R) acute lymphoblastic leukemia (ALL)
are dismal. The efficacy and safety of intravenous clofarabine 40 mg/m2 per day …

Purpose Despite the common underlying translocation t (11; 14) involving cyclin D1 that is
present in nearly all cases of mantle-cell lymphoma (MCL), the clinical course of the disease …

Methods Essential information on BBB cellular microenvironment were reviewed and
discussed towards impacts of BBB on brain drug delivery and targeting. Results Brain …

A prospective multicenter study was conducted to characterize the pharmacokinetics (PK)
and pharmacodynamics (PD) of fludarabine plasma (f-ara-a) and intracellular triphosphate (f …

Cytotoxic deoxynucleoside analogues are widely used in the treatment of haematological
malignancies and solid tumours. Their metabolism and mechanisms of action are relatively …