In recent years, there have been huge advances in the use of genetically modified mice to
study pathophysiological mechanisms involved in schizophrenia. This has allowed rapid …

The prefrontal cortex (PFC), seat of the highest-order cognitive functions, constitutes a
conglomerate of highly specialized brain areas and has been implicated to have a role in …

Schizophrenia is a severe mental illness that afflicts nearly 1% of the world's population.
One of the cardinal pathological features of schizophrenia is perturbation in synaptic …

Patients with schizophrenia are at an increased risk for the development of depression.
Overlap in the symptoms and genetic risk factors between the two disorders suggests a …

Schizophrenia has long been considered as a disorder with multifactorial origins. Recent
discoveries have advanced our understanding of the genetic architecture of the disease …

Cannabis use confers a two-fold increase in the risk for psychosis, with adolescent use
conferring even greater risk. A high–low activity catechol-O-methyltransferase (COMT) …

There is a paucity of animal models by which the contributions of environmental and genetic
factors to the pathobiology of psychosis can be investigated. This study examined the …

Abstract Neuregulin 1 (NRG1) is a growth factor involved in neurodevelopment and
plasticity. It is a schizophrenia candidate gene, and hippocampal expression of the NRG1 …

Recent genetic linkage analysis has shown that LRRTM1 (Leucine rich repeat
transmembrane neuronal 1) is associated with schizophrenia. Here, we characterized …

Abstract Neuregulin‐1 (NRG1) has been shown to play a role in glutamatergic
neurotransmission and is a risk gene for schizophrenia, in which there is evidence for …