Glaucoma as Neurodegeneration in the Brain

JW Chan, NCY Chan, AA Sadun - Eye and brain, 2021 - Taylor & Francis
Glaucoma, a group of diseases characterized by progressive optic nerve degeneration that
results in irreversible blindness, can be considered a neurodegenerative disorder of both …

Changes of visual pathway and brain connectivity in glaucoma: a systematic review

R Nuzzi, L Dallorto, T Rolle - Frontiers in Neuroscience, 2018 - frontiersin.org
Background: Glaucoma is a leading cause of irreversible blindness worldwide. The
increasing interest in the involvement of the cortical visual pathway in glaucomatous patients …

Demyelination precedes axonal loss in the transneuronal spread of human neurodegenerative disease

Y You, C Joseph, C Wang, V Gupta, S Liu, C Yiannikas… - Brain, 2019 - academic.oup.com
The spread of neurodegeneration through the human brain network is reported as
underlying the progression of neurodegenerative disorders. However, the exact …

Diffuse brain damage in normal tension glaucoma

A Giorgio, J Zhang, F Costantino… - Human brain …, 2018 - Wiley Online Library
Brain changes within and beyond the visual system have been demonstrated in primary
open angle glaucoma (POAG), the most common type of glaucoma. These changes have …

Comparison of multiple tractography methods for reconstruction of the retinogeniculate visual pathway using diffusion MRI

J He, F Zhang, G Xie, S Yao, Y Feng… - Human Brain …, 2021 - Wiley Online Library
The retinogeniculate visual pathway (RGVP) conveys visual information from the retina to
the lateral geniculate nucleus. The RGVP has four subdivisions, including two decussating …

Convolutional neural network-based classification of glaucoma using optic radiation tissue properties

J Kruper, A Richie-Halford, NC Benson… - Communications …, 2024 - nature.com
Background Sensory changes due to aging or disease can impact brain tissue. This study
aims to investigate the link between glaucoma, a leading cause of blindness, and alterations …

Altered coupling of cerebral blood flow and functional connectivity strength in visual and higher order cognitive cortices in primary open angle glaucoma

Q Wang, X Qu, W Chen, H Wang… - Journal of Cerebral …, 2021 - journals.sagepub.com
Primary open-angle glaucoma (POAG) has been suggested to be a neurodegenerative
disease associated with altered cerebral vascular hemodynamics and widespread …

Effect of glaucoma on eye movement patterns and laboratory-based hazard detection ability

SSY Lee, AA Black, JM Wood - PloS one, 2017 - journals.plos.org
Purpose The mechanisms underlying the elevated crash rates of older drivers with
glaucoma are poorly understood. A key driving skill is timely detection of hazards; however …

In vivo imaging of structural, metabolic and functional brain changes in glaucoma

A Kasi, MA Faiq, KC Chan - Neural Regeneration Research, 2019 - journals.lww.com
Glaucoma, the world's leading cause of irreversible blindness, is a condition for which
elevated intraocular pressure is currently the only modifiable risk factor. However, the …

Trans-synaptic degeneration in the visual pathway: neural connectivity, pathophysiology, and clinical implications in neurodegenerative disorders

S Sharma, N Chitranshi, R Vander Wall… - Survey of …, 2022 - Elsevier
There is a strong interrelationship between eye and brain diseases. It has been shown that
neurodegenerative changes can spread bidirectionally in the visual pathway along neuronal …