DNA topoisomerases (TOPs) are complex enzymatic machines with extraordinary capacity
to maintain DNA topology during torsion-intensive steps of replication and transcription …

Reactive oxygen species (ROS) are an array of derivatives of molecular oxygen that
participate in multiple physiological processes under the control of redox homeostasis …

The transient receptor potential vanilloid 1 (TRPV1) is a non-selective cation channel that is
activated by capsaicin (CAP), the main component of chili pepper. Despite studies in several …

Multiple sclerosis (MS) is an inflammatory-mediated demyelinating disease of the central
nervous system (CNS). Although studies have demonstrated that microglia facilitate …

Background Microglia, the brain-resident macrophages perform immune surveillance and
engage with pathological processes resulting in phenotype changes necessary for …

b-galactosidase is a lysosomal enzyme that removes terminal galactose residues from
glycolipids and glycoproteins. It is upregulated in, and used as a marker for, senescent cells …

DNA and RNA nanostructures are being investigated as therapeutics, vaccines, and drug
delivery systems. These nanostructures can be functionalized with guests ranging from …

While efforts to identify microglial subtypes have recently accelerated, the relation of
transcriptomically defined states to function has been largely limited to in silico annotations …

Microglia aggregate in regions of active inflammation and demyelination in the CNS of
multiple sclerosis (MS) patients and are considered pivotal in the disease process. Targeting …

Spinal cord injury is a complicated medical condition both from the clinician's point of view in
terms of management and from the patient's perspective in terms of unsatisfactory recovery …