Upregulation of breathing rate during running exercise by central locomotor circuits in mice

C Hérent, S Diem, G Usseglio, G Fortin… - Nature …, 2023 - nature.com
While respiratory adaptation to exercise is compulsory to cope with the increased metabolic
demand, the neural signals at stake remain poorly identified. Using neural circuit tracing and …

Proximal and distal spinal neurons innervating multiple synergist and antagonist motor pools

R Ronzano, C Lancelin, GS Bhumbra, RM Brownstone… - Elife, 2021 - elifesciences.org
Motoneurons (MNs) control muscle contractions, and their recruitment by premotor circuits is
tuned to produce accurate motor behaviours. To understand how these circuits coordinate …

[HTML][HTML] The role of intraspinal sensory neurons in the control of quadrupedal locomotion

K Gerstmann, N Jurčić, E Blasco, S Kunz… - Current Biology, 2022 - cell.com
From swimming to walking and flying, animals have evolved specific locomotor strategies to
thrive in different habitats. All types of locomotion depend on the integration of motor …

Regional cytoarchitecture of the adult and developing mouse enteric nervous system

R Hamnett, LB Dershowitz, V Sampathkumar, Z Wang… - Current Biology, 2022 - cell.com
The organization and cellular composition of tissues are key determinants of their biological
function. In the mammalian gastrointestinal (GI) tract, the enteric nervous system (ENS) …

Spinal premotor interneurons controlling antagonistic muscles are spatially intermingled

R Ronzano, S Skarlatou, BK Barriga, BA Bannatyne… - Elife, 2022 - elifesciences.org
Elaborate behaviours are produced by tightly controlled flexor-extensor motor neuron
activation patterns. Motor neurons are regulated by a network of interneurons within the …

The structure of the spinal cord ependymal region in adult humans is a distinctive trait among mammals

A Torrillas De La Cal, B Paniagua-Torija… - Cells, 2021 - mdpi.com
In species that regenerate the injured spinal cord, the ependymal region is a source of new
cells and a prominent coordinator of regeneration. In mammals, cells at the ependymal …

Absent phasing of respiratory and locomotor rhythms in running mice

C Herent, S Diem, G Fortin, J Bouvier - Elife, 2020 - elifesciences.org
Examining whether and how the rhythms of limb and breathing movements interact is highly
informative about the mechanistic origin of hyperpnoea during running exercise. However …

Natural loss of function of ephrin-B3 shapes spinal flight circuitry in birds

B Haimson, O Meir, R Sudakevitz-Merzbach… - Science …, 2021 - science.org
Flight in birds evolved through patterning of the wings from forelimbs and transition from
alternating gait to synchronous flapping. In mammals, the spinal midline guidance molecule …

Motor dysfunction in Drosophila melanogaster as a biomarker for developmental neurotoxicity

A Cabrita, AM Medeiros, T Pereira, AS Rodrigues… - Iscience, 2022 - cell.com
Adequate alternatives to conventional animal testing are needed to study developmental
neurotoxicity (DNT). Here, we used kinematic analysis to assess DNT of known (toluene …

Upregulation of breathing rate during running exercise by central locomotor circuits

C Hérent, S Diem, G Fortin, J Bouvier - bioRxiv, 2021 - biorxiv.org
While respiratory adaptation to exercise is compulsory to cope with the increased metabolic
supply to body tissues and with the necessary clearing of metabolic waste, the neural …