From gut dysbiosis to altered brain function and mental illness: mechanisms and pathways
The human body hosts an enormous abundance and diversity of microbes, which perform a
range of essential and beneficial functions. Our appreciation of the importance of these …
range of essential and beneficial functions. Our appreciation of the importance of these …
The role of inflammation and microglial activation in the pathophysiology of psychiatric disorders
Psychiatric disorders, including major depressive disorder (MDD), bipolar disorder (BD) and
schizophrenia, affect a significant percentage of the world population. These disorders are …
schizophrenia, affect a significant percentage of the world population. These disorders are …
[HTML][HTML] Brain changes in a maternal immune activation model of neurodevelopmental brain disorders
L Bergdolt, A Dunaevsky - Progress in neurobiology, 2019 - Elsevier
The developing brain is sensitive to a variety of insults. Epidemiological studies have
identified prenatal exposure to infection as a risk factor for a range of neurological disorders …
identified prenatal exposure to infection as a risk factor for a range of neurological disorders …
Maternal immune activation: reporting guidelines to improve the rigor, reproducibility, and transparency of the model
Abstract The 2017 American College of Neuropychopharmacology (ACNP) conference
hosted a Study Group on 4 December 2017, Establishing best practice guidelines to …
hosted a Study Group on 4 December 2017, Establishing best practice guidelines to …
An overview of animal models related to schizophrenia
Schizophrenia is a heterogeneous psychiatric disorder that is poorly treated with current
therapies. In this brief review, we provide an update regarding the use of animal models to …
therapies. In this brief review, we provide an update regarding the use of animal models to …
Environmental enrichment alters neurobehavioral development following maternal immune activation in mice offspring with epilepsy
Epilepsy is a chronic brain disease affecting millions of people worldwide. Anxiety-related
disorders and cognitive deficits are common in patients with epilepsy. Previous studies have …
disorders and cognitive deficits are common in patients with epilepsy. Previous studies have …
Maternal inflammation and neurodevelopmental programming: a review of preclinical outcomes and implications for translational psychiatry
SB Gumusoglu, HE Stevens - Biological psychiatry, 2019 - Elsevier
Early disruptions to neurodevelopment are highly relevant to understanding both psychiatric
risk and underlying pathophysiology that can be targeted by new treatments. Much …
risk and underlying pathophysiology that can be targeted by new treatments. Much …
Pregnancy, viral infection, and COVID-19
Pregnancy comprises a unique immunological condition, to allow fetal development and to
protect the host from pathogenic infections. Viral infections during pregnancy can disrupt …
protect the host from pathogenic infections. Viral infections during pregnancy can disrupt …
Oxidative stress, prefrontal cortex hypomyelination and cognitive symptoms in schizophrenia
DA Maas, A Vallès, GJM Martens - Translational psychiatry, 2017 - nature.com
Schizophrenia (SZ) is a neurodevelopmental disorder with a broad symptomatology,
including cognitive symptoms that are thought to arise from the prefrontal cortex (PFC). The …
including cognitive symptoms that are thought to arise from the prefrontal cortex (PFC). The …
Maternal immune activation in neurodevelopmental disorders
Converging lines of evidence from basic science and clinical studies suggest a relationship
between maternal immune activation (MIA) and neurodevelopmental disorders such as …
between maternal immune activation (MIA) and neurodevelopmental disorders such as …