Aging is characterized by a progressive deterioration of physiological integrity, leading to
impaired functional ability and ultimately increased susceptibility to death. It is a major risk …

Neural recording electrode technologies have contributed considerably to neuroscience by
enabling the extracellular detection of low-frequency local field potential oscillations and …

The mechanisms underlying the pathophysiology and treatment of depression and stress-
related disorders remain unclear, but studies in depressed patients and rodent models are …

Cognitive dysfunction in aging is a major biomedical challenge. Whether treatment with
klotho, a longevity factor, could enhance cognition in human-relevant models such as in …

The world's population is aging, bringing about an ever‐greater burden of mental disorders
in older adults. Given multimorbidities, the mental health care of these people and their …

Depression is a common, devastating illness. Current pharmacotherapies help many
patients, but high rates of a partial response or no response, and the delayed onset of the …

Cognitive decline remains an unaddressed problem for the elderly. We show that
myelination is highly active in young mice and greatly inhibited in aged mice, coinciding with …

This article reviews the cognitive changes that occur with normal aging, the structural and
functional correlates of these cognitive changes, and the prevalence and cognitive effects of …

The pathophysiology and treatment of depression have been the focus of intense research
and while there is much that remains unknown, modern neurobiological approaches are …

Microglia are resident macrophages of the central nervous system and significantly
contribute to overall brain function by participating in phagocytosis during development …