Interaction of the T cell receptor (TCR) with an MHC-antigenic peptide complex results in
changes at the molecular and cellular levels in T cells. The outside environmental cues are …

CD45 is an evolutionary highly conserved receptor protein tyrosine phosphatase exclusively
expressed on all nucleated cells of the hematopoietic system. It is characterized by the …

In the absence of cell surface cancer-specific antigens, immunotherapies such as chimeric
antigen receptor (CAR) T cells, monoclonal antibodies, or bispecific T cell engagers typically …

▪ Abstract Regulation of tyrosine phosphorylation is a critical control point for integration of
environmental signals into cellular responses. This regulation is mediated by the reciprocal …

The American Academy of Allergy, Asthma & Immunology (AAAAI) and the American
College of Allergy, Asthma & Immunology (ACAAI) have jointly accepted responsibility for …

In the last years, advances in molecular genetics and immunology have resulted in the
identification of a growing number of genes causing primary immunodeficiencies (PIDs) in …

Background X-linked severe combined immunodeficiency due to a mutation in the gene
encoding the common γ (γc) chain is a lethal condition that can be cured by allogeneic stem …

Background The approach to the diagnosis of severe combined immunodeficiency disease
(SCID) and related disorders varies among institutions and countries. Objectives The …

Severe combined immunodeficiencies (SCIDs) comprise a group of rare, monogenic
diseases that are characterized by an early onset and a profound block in the development …

Can genetic and clinical findings made in a single patient be considered sufficient to
establish a causal relationship between genotype and phenotype? We report that up to 49 of …