The development of small molecule modulators of NO/cGMP signaling for use in the CNS
has lagged far behind the use of such clinical agents in the periphery, despite the central …

Cerebral ischemia is a multi-faceted neurodegenerative pathology that causes cellular injury
to neurons within the central nervous system. In light of the underlying mechanisms being …

Background Clinical failures singularly targeting amyloid-β pathology indicate a critical need
for alternative Alzheimer's disease (AD) therapeutic strategies. The mixed pathology …

Perinatal hypoxia–ischemia (HI) gives rise to inadequate substrate supply to the brain
tissue, resulting in damage to neural cells. Previous studies at different time points of …

Oxidative stress induced by lipid peroxidation products (LPP) accompanies aging and has
been hypothesized to exacerbate the secondary cascade in traumatic brain injury (TBI) …

Nitric oxide (NO)/solube GC (sGC)/cGMP signaling is important for modulating synaptic
transmission and plasticity in the hippocampus and cerebral cortex, which are critical for …

Learning and memory deficits in Alzheimer's disease (AD) result from synaptic failure and
neuronal loss, the latter caused in part by excitotoxicity and oxidative stress. A therapeutic …

Tonic inhibitory currents, mediated by extrasynaptic GABAA receptors, are elevated at a
delay following stroke. Flavonoids minimise the extent of cellular damage following stroke …

Perinatal hypoxia–ischemia (HI) occurs in 0.2%–0.4% of all live births, with 100% O2
resuscitation (HHI) remaining a standard clinical treatment. HI produces a broad spectrum of …

Pregnancy is a critical period for brain metabolic programming, being affected by individual
environment, such as nutrition, stress, and physical exercise. In this context, we previously …