Highlights•Flavivirus replication occurs on modified ER membranes called vesicle packets
(Vp) and membrane vesicles (Ve).•Flavivirus non-structural proteins are implicated in …

Tick-borne encephalitis virus (TBEV) is a growing health concern. It causes a severe
disease that can lead to permanent neurological complications or death and the incidence …

Flaviviruses are a group of single-stranded, positive-sense RNA viruses that generally
circulate between arthropod vectors and susceptible vertebrate hosts, producing significant …

Dengue virus (DENV) is a mosquito-transmitted flavivirus that can cause severe disease in
humans and is considered a reemerging pathogen of significant importance to public health …

Many viruses belonging to the Flaviviridae family are transmitted by invertebrate vectors.
Among those transmitted by mosquitos, there are many human pathogens of great medical …

Efficient antiviral immunity requires interference with virus replication at multiple layers
targeting diverse steps in the viral life cycle. We describe here a novel flavivirus inhibition …

We present structures of three immature tick-borne encephalitis virus (TBEV) isolates. Our
atomic models of the major viral components, the E and prM proteins, indicate that the pr …

Based on the immunogenicity of domain III from the Envelope protein of dengue virus as
well as the proven protective capacity of the capsid antigen, we have designed a novel …

Dengue is the most important cause of mosquito-borne virus diseases in tropical and
subtropical regions in the world. Severe clinical outcomes such as dengue hemorrhagic …

The Flavivirus genus of the Flaviviridae family of enveloped single-stranded RNA viruses
encompasses more than 70 members, many of which cause significant disease in humans …