The origin of life is a fascinating, unresolved problem whose deciphering would have
important scientific, epistemological and social implications. Over time, philosophers and …

There are many instances in life when the environment plays a critical role in the health
outcomes of an individual, yet none more so than those experienced in fetal and neonatal …

One carbon metabolism or methyl transfer, a crucial component of metabolism in all cells
and tissues, supports the critical function of synthesis of purines, thymidylate and …

Methionine and folate are the key components of one carbon metabolism, providing the
methyl groups for numerous methyl transferase reactions via the ubiquitous methyl donor, s …

In this essay, we highlight how litter size in rodents is a strong determinant of neonatal
growth and long-term metabolic health. Based on these effects, we strongly advise that …

The intrauterine environment is a major contributor to normal physiological growth and
development of an individual. Disturbances at this critical time can affect the long-term …

Background: It is now widely accepted that the early-life nutritional environment is important
in determining susceptibility to metabolic diseases. In particular, intra-uterine growth …

The prevalence of age-associated disease is increasing at a striking rate globally. It is
known that a strong association exists between a suboptimal maternal and/or early-life …

Our aim was to determine the effect of exposure to maternal obesity or to maternal weight
loss around conception on the programming of hepatic insulin signaling in the offspring. We …

Adverse prenatal environment, such as intrauterine growth retardation (IUGR), increases the
risk for negative neurobehavioral outcomes. IUGR, affecting approximately 10% of all US …