The success of checkpoint inhibitors has accelerated the clinical implementation of a vast
mosaic of single agents and combination immunotherapies. However, the lack of clinical …

Hypertension affects 30% of adults and is the leading risk factor for heart attack and stroke.
Traditionally, hypertension has been regarded as a disorder of two systems that are involved …

Abstract In coronavirus disease 2019 (COVID-19), hypertension and cardiovascular
diseases are major risk factors for critical disease progression. However, the underlying …

Active research at the frontiers of immunology and neuroscience has identified multiple
points of interaction and communication between the immune system and the nervous …

Recent advances have directed our knowledge of the immune system from a narrative of
“self” versus “nonself” to one in which immune function is critical for homeostasis of organs …

The vagus nerve is a mixed nerve, comprising 80% afferent fibers and 20% efferent fibers. It
allows a bidirectional communication between the central nervous system and the digestive …

Inflammation is a physiological response to aggression of pathogenic agents aimed at
eliminating the aggressor agent and promoting healing. Excessive inflammation, however …

Hypertension is a global health problem, with> 1.3 billion individuals with high blood
pressure worldwide. In this Review, we present an inflammatory paradigm for hypertension …

Acetylcholine (ACh) is best known as a neurotransmitter and was the first such molecule
identified. ACh signalling in the neuronal cholinergic system has long been known to …

T and B cells, macrophages and dendritic cells (DCs) all express most of the components
necessary for a functional cholinergic system. This includes choline acetyltransferase …