During the past decade a plethora of studies have unravelled the multiple roles of nitric
oxide (NO) in airway physiology and pathophysiology. In the respiratory tract, NO is …

Rationale: Angiographic investigation suggests that pulmonary vascular remodeling in
smokers is characterized by distal pruning of the blood vessels. Objectives: Using volumetric …

Pulmonary hypertension (PH) associated with parenchymal lung diseases is one of the most
common forms of PH. Studies in patients with advanced COPD and hypoxemia have shown …

Right ventricular (RV) dysfunction determines prognosis in patients with chronic pulmonary
disease. We examined the relative prognostic potential of measures of systolic, diastolic …

The cardiac manifestations of chronic obstructive pulmonary disease (COPD) are numerous.
Impairments of right ventricular dysfunction and pulmonary vascular disease are well known …

The complex nature of interactions between the pulmonary and cardiovascular systems is
becoming increasingly appreciated. Pulmonary vascular abnormalities are frequently …

Background Mortality from COPD is increasing worldwide, but detailed causes of death are
rarely assessed, particularly in low-income countries. Methods In a retrospective study, we …

Chronic hypoxia caused by migration of native sea‐level dwellers to high altitude or chronic
lung disease leads to the development of increased pulmonary vascular resistance and …

Chronic or sustained pulmonary hypertension is a complication of residence at high
altitudes and chronic lung diseases such as chronic obstructive pulmonary disease, cystic …

Pulmonary hypertension (PH) is an important complication in the natural history of chronic
obstructive pulmonary disease (COPD). Its presence is associated with reduced survival and …