Oxidative stress (OS) has the ability to damage different molecules and cellular structures,
altering the correct function of organs and systems. OS accumulates in the body by …

Stroke and late-onset Alzheimer's disease (AD) are risk factors for each other; the
comorbidity of these brain disorders in aging individuals represents a significant challenge …

Acetylcholine (ACh) has a crucial role in the peripheral and central nervous systems. The
enzyme choline acetyltransferase (ChAT) is responsible for synthesizing ACh from acetyl …

A simple, primary amine bearing a C10H15 alkyl residue was found to display potent anti-
Influenza A properties in 1964. 1 Soon thereafter, antiviral activity of this amine was found …

Drugs, their targets and the nature and number of drug targets | Nature Reviews Drug Discovery
Skip to main content Thank you for visiting nature.com. You are using a browser version with …

Few genome-wide association studies (GWAS) account for environmental exposures, like
smoking, potentially impacting the overall trait variance when investigating the genetic …

Neuroprotective drugs tested in clinical trials, particularly those that block N-methyl-d-
aspartate-sensitive glutamate receptors (NMDARs), have failed miserably in large part …

The neurotransmitter glutamate activates several classes of metabotropic receptor and three
major types of ionotropic receptor–α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid …

Memantine is a clinically useful drug in many neurological disorders, including Alzheimer's
disease. The principal mechanism of action of memantine is believed to be the blockade of …

Numerous variations on structural motifs exist within pharmaceutical compounds that have
entered the clinic. These variations have amounted over many decades based on years of …