Cohesin mediates chromatin loop formation across the genome by extruding chromatin
between convergently oriented CTCF-binding elements. Recent studies indicate that …

V (D) J recombination assembles immunoglobulin and T cell receptor genes during
lymphocyte development through a series of carefully orchestrated DNA breakage and …

Endometriosis is defined as the presence of endometrial-like glands and stroma located
outside the uterine cavity. This common, estrogen dependent, inflammatory condition affects …

The critical initial step in V (D) J recombination, binding of RAG1 and RAG2 to
recombination signal sequences flanking antigen receptor V, D, and J gene segments, has …

Summary RAG initiates antibody V (D) J recombination in developing lymphocytes by
generating" on-target" DNA breaks at matched pairs of bona fide recombination signal …

The RAG1 endonuclease, together with its cofactor RAG2, is essential for V (D) J
recombination but is a potent threat to genome stability. The sources of RAG1 mis-targeting …

The modular, noncontiguous architecture of the antigen receptor genes necessitates their
assembly through V (D) J recombination. This program of DNA breakage and rejoining …

An effective adaptive immune system depends on the ability of developing B and T cells to
generate diverse immunoglobulin (Ig) and T cell receptor repertoires, respectively. Such …

The dynamic folding of genomes regulates numerous biological processes, including
antigen receptor (AgR) gene assembly. We show that, unlike other AgR loci, homotypic …

Allelic exclusion requires that the two alleles at antigen-receptor loci attempt to recombine
variable (V), diversity (D), and joining (J) gene segments [V (D) J recombination] …