Non-invasive evaluation of cerebral microvasculature using pre-clinical MRI: principles, advantages and limitations

B Callewaert, EAV Jones, U Himmelreich, W Gsell - Diagnostics, 2021 - mdpi.com
Alterations to the cerebral microcirculation have been recognized to play a crucial role in the
development of neurodegenerative disorders. However, the exact role of the microvascular …

Imaging vascular and hemodynamic features of the brain using dynamic susceptibility contrast and dynamic contrast enhanced MRI

CC Quarles, LC Bell, AM Stokes - Neuroimage, 2019 - Elsevier
In the context of neurologic disorders, dynamic susceptibility contrast (DSC) and dynamic
contrast enhanced (DCE) MRI provide valuable insights into cerebral vascular function …

Concurrent measurement of perfusion parameters related to small blood vessels and cerebrospinal fluid circulation in the human brain using dynamic dual‐spin‐echo …

D Cao, Y Sun, Y Li, P Su, JJ Pillai, Y Qiao… - NMR in …, 2023 - Wiley Online Library
Accumulating evidence from recent studies has indicated the importance of studying the
interaction between the microvascular and lymphatic systems in the brain. To date, most …

[HTML][HTML] A population-based digital reference object (DRO) for optimizing dynamic susceptibility contrast (DSC)-MRI methods for clinical trials

NB Semmineh, AM Stokes, LC Bell… - …, 2017 - pmc.ncbi.nlm.nih.gov
The standardization and broad-scale integration of dynamic susceptibility contrast (DSC)-
magnetic resonance imaging (MRI) have been confounded by a lack of consensus on DSC …

Evaluation of single bolus, dual-echo dynamic susceptibility contrast MRI protocols in brain tumor patients

AM Stokes, M Bergamino, L Alhilali… - Journal of Cerebral …, 2021 - journals.sagepub.com
Relative cerebral blood volume (rCBV) obtained from dynamic susceptibility contrast (DSC)
MRI is adversely impacted by contrast agent leakage in brain tumors. Using simulations, we …

Assessment of a simplified spin and gradient echo (sSAGE) approach for human brain tumor perfusion imaging

AM Stokes, JT Skinner, T Yankeelov… - Magnetic resonance …, 2016 - Elsevier
The goal of this study was to validate a simplified spin-and gradient-echo (sSAGE) approach
to obtain T 1-corrected dynamic susceptibility contrast magnetic resonance imaging (DSC …

Accelerated whole‐brain perfusion imaging using a simultaneous multislice spin‐echo and gradient‐echo sequence with joint virtual coil reconstruction

MK Manhard, B Bilgic, C Liao, SH Han… - Magnetic resonance …, 2019 - Wiley Online Library
Purpose Dynamic susceptibility contrast imaging requires high temporal sampling, which
poses limits on achievable spatial coverage and resolution. Additionally, more encoding …

Investigating the relationship between multi-scale perfusion and white matter microstructural integrity in patients with relapsing-remitting MS

NJ Sisco, A Borazanci, R Dortch… - Multiple Sclerosis …, 2021 - journals.sagepub.com
Background Multiple sclerosis is characterized by the formation of central nervous system
demyelinating lesions with microvasculature inflammation. Objective Evaluate how lesion …

A 3D dual‐echo spiral sequence for simultaneous dynamic susceptibility contrast and dynamic contrast‐enhanced MRI with single bolus injection

Z Li, D Wang, MB Ooi, P Choudhary… - Magnetic resonance …, 2024 - Wiley Online Library
Purpose Perfusion MRI reveals important tumor physiological and pathophysiologic
information, making it a critical component in managing brain tumor patients. This study …

Perfusion weighted imaging using combined gradient/spin echo EPIK: Brain tumour applications in hybrid MR‐PET

NJ Shah, NA da Silva, SD Yun - Human brain mapping, 2021 - Wiley Online Library
Advanced perfusion‐weighted imaging (PWI) methods that combine gradient echo (GE) and
spin echo (SE) data are important tools for the study of brain tumours. In PWI, single‐shot …