Context Recent public outcry has highlighted the rising cost of prescription drugs worldwide,
which in several disease areas outpaces other health care expenditures and results in a …

The development of new immunosuppressive drugs has slowed markedly over the past
several years, and the outlook that improved therapy will be available to the next generation …

Sequential window acquisition of all theoretical fragment-ion spectra (SWATH) is a data-
independent acquisition (DIA) strategy that requires a specific spectral library to generate …

In-vitro protein refolding is one of the key rate-limiting unit operations in manufacturing of
fusion proteins such as peptibodies expressed using E. coli. Dilution-assisted refolding is …

Introduction This study compared the characteristics of new human drugs approved by the
Food and Drug Administration (FDA), the European Medicine Agency (EMA), and …

Background Approved drugs must be included on the so-called “special list”(SL) by the
Federal Office for Public Health (FOPH) to be reimbursed by the social health insurance in …

The replacement of the European Union (EU) Clinical Trials Directive by the new Clinical
Trials Regulation (CTR), which entered into force on 16 June 2014 but will not apply before …

Given the globalization of the pharmaceutical industry, harmonizing the drug regulatory
environment of the United States (US) and European Union (EU) is becoming increasingly …

Background Successful first-generation drugs can be converted with small alterations to"
second-generation drugs," which are cheaper to develop and may pose less financial risk …

Before now, biological systems could only be expressed in terms of linear relationships,
however, as knowledge grows and new techniques of analysis on biological systems is …