Abstract Purpose of Review To briefly review epidemiology and pathophysiology of SICM
and provide a more extensive review of the data on diagnostic and management strategies …

Coronavirus disease (COVID‐19) caused by the novel coronavirus (SARS‐CoV‐2) has
rapidly spread across the globe affecting 213 countries or territories with greater than six …

Background Vitamin C is an essential water-soluble nutrient that functions as a key
antioxidant and has been proven to be effective for boosting immunity. In this study, we …

Background The global burden of sepsis is estimated as 15 to 19 million cases annually,
with a mortality rate approaching 60% in low-income countries. Methods In this retrospective …

Background Parenterally administered ascorbic acid modulates sepsis-induced
inflammation and coagulation in experimental animal models. The objective of this …

Background The lack of a reliable scoring system that predicts the development of septic
shock and death precludes comparison of disease and/or treatment outcomes in animal …

Most vertebrates can synthesize vitamin C with synthesis increasing during stress. Humans,
however, have lost the ability to synthesize vitamin C. Vitamin C is an important anti-oxidant …

Oxidative stress resulting from the disproportion of oxidants and antioxidants contributes to
both physiological and pathological conditions in sepsis. To combat this, the antioxidant …

There is no Food and Drug Administration-approved treatment for acute respiratory distress
syndrome (ARDS), in spite of the relatively large number of patients with the diagnosis. In …

Vitamin C (VitC) or ascorbic acid (AscA), a cofactor for collagen synthesis and a primary
antioxidant, is rapidly consumed post‐wounding. Parenteral VitC administration suppresses …