1, 25-Dihydroxvitamin D3 [1, 25 (OH) 2D3] is the hormonally active form of vitamin D. The
genomic mechanism of 1, 25 (OH) 2D3 action involves the direct binding of the 1, 25 (OH) …

The IL-1 family of cytokines currently comprises of seven ligands with pro-inflammatory
activity (IL-1α and IL-1β, IL-18, IL-33, IL-36α, IL-36β, IL-36γ) as well as two ligands with anti …

Vitamin D is not really a vitamin but the precursor to the potent steroid hormone calcitriol,
which has widespread actions throughout the body. Calcitriol regulates numerous cellular …

The population-based association between low vitamin D status and increased cancer risk
can be inconsistent, but it is now generally accepted. These relationships link low serum …

Tumor cells along with a small proportion of cancer stem cells exist in a stromal
microenvironment consisting of vasculature, cancer-associated fibroblasts, immune cells …

Oral cancer is known as one of the most common cancers, with a poor prognosis, related to
delayed clinical diagnosis, either due to the lack of particular biomarkers related to the …

Increasing interest in studying the role of vitamin D in cancer has been provided by the
scientific literature during the last years, although mixed results have been reported. Vitamin …

Epidemiologic data suggest that the incidence and severity of many types of cancer
inversely correlates with indices of vitamin D status. The vitamin D receptor (VDR) is highly …

Context: There is increasing evidence that Vitamin D (Vit D) and its metabolites, besides
their well-known calcium-related functions, may also exert antiproliferative, pro …

Abstract The interleukin-1 (IL-1) family is one of the first described cytokine families and
consists of eight cytokines (IL-1β, IL-1α, IL-18, IL-33, IL-36α, IL-36β, IL-36γ and IL-37) and …