Drug consumption is driven by a drug's pharmacological effects, which are experienced as
rewarding, and is influenced by genetic, developmental, and psychosocial factors that …

Insula function is considered critical for many motivated behaviors, with proposed functions
ranging from attention, behavioral control, emotional regulation, goal-directed and aversion …

Despite decades of research on neurobiological mechanisms of psychostimulant addiction,
the only effective treatment for many addicts is contingency management, a behavioral …

Substance use disorders (SUDs) are a growing public health concern with only a limited
number of approved treatments. However, even approved treatments are subject to limited …

Abstract MCGREGOR, MS, and RT LaLumiere. Still a “hidden island”? The rodent insular
cortex in drug seeking, reward, and risk. NEUROSCI BIOBEHAV REV 21 (1) XXX-XXX …

Compulsion-like alcohol drinking (CLAD), where consumption continues despite negative
consequences, is a major obstacle to treating alcohol use disorder. The locus coeruleus …

We recently developed a rat model of relapse to drug seeking after food choice-induced
voluntary abstinence. Here, we used this model to study the role of the orbitofrontal cortex …

Background Convergent preclinical and clinical evidence has linked the anterior insula to
impulsivity and alcohol-associated compulsivity. The anterior insula is functionally …

Drugs of abuse, including alcohol, ablate the expression of specific forms of long-term
synaptic depression (LTD) at glutamatergic synapses in dorsal striatum (DS), a brain region …

Addiction is a chronic brain disease that has dramatic health and socioeconomic
consequences worldwide. Multiple approaches have been used for decades to clarify the …