The role of fibronectin (FN) in tumorigenesis and malignant progression has been highly
controversial. Cancerous FN plays a tumor-suppressive role, whereas it is pro-metastatic …

Activating mutations in the epidermal growth factor receptor gene occur as early cancer-
driving clonal events in a subset of patients with non-small cell lung cancer (NSCLC) and …

The emergence of resistance to epidermal growth factor receptor (EGFR) tyrosine kinase
inhibitors (TKIs) in non-small cell lung cancer (NSCLC) with activating EGFR mutations is a …

The insulin-like growth factor (IGF) system, which is constituted by the IGF-1 and IGF-2
peptide hormones, their corresponding receptors and several IGF binding proteins, is …

Inhibition of the epidermal growth factor receptor (EGFR) is an important strategy when
treating non-small cell lung cancer (NSCLC) patients. However, intrinsic resistance or …

Epithelial to mesenchymal transition (EMT) is a process that allows an epithelial cell to
acquire a mesenchymal phenotype through multiple biochemical changes resulting in an …

Hypoxic tumor microenvironment (HTM) is considered to promote metabolic changes,
oncogene activation and epithelial mesenchymal transition, and resistance to chemo-and …

The underlying mechanisms for acquired resistance to epidermal growth factor receptor-
tyrosine kinase inhibitors (EGFR-TKIs) in about 30%-40% of non-small cell lung cancer …

Oral cancer is a serious and fatal disease. Cisplatin is the first line of chemotherapeutic
agent for oral cancer therapy. However, the development of drug resistance and severe side …

The proline synthesis is importantly involved in tumor growth under hypoxia, while the
underlying mechanism remains to be further investigated. Here we show that pyrroline-5 …