Roles and mechanisms of exosomal non-coding RNAs in human health and diseases

C Li, YQ Ni, H Xu, QY Xiang, Y Zhao, JK Zhan… - Signal transduction and …, 2021 - nature.com
Exosomes play a role as mediators of cell-to-cell communication, thus exhibiting pleiotropic
activities to homeostasis regulation. Exosomal non-coding RNAs (ncRNAs), mainly …

The epigenetics of aging and neurodegeneration

R Lardenoije, A Iatrou, G Kenis, K Kompotis… - Progress in …, 2015 - Elsevier
Epigenetics is a quickly growing field encompassing mechanisms regulating gene
expression that do not involve changes in the genotype. Epigenetics is of increasing …

The role of exosomal microRNAs and oxidative stress in neurodegenerative diseases

X Wang, Y Zhou, Q Gao, D Ping, Y Wang… - Oxidative medicine …, 2020 - Wiley Online Library
Neurodegenerative diseases including Alzheimer's disease and Parkinson's disease are
aging‐associated diseases with irreversible damage of brain tissue. Oxidative stress is …

Role of MicroRNAs in Parkinson's disease

SY Goh, YX Chao, ST Dheen, EK Tan… - International journal of …, 2019 - mdpi.com
Parkinson's disease (PD) is a disabling neurodegenerative disease that manifests with
resting tremor, bradykinesia, rigidity and postural instability. Since the discovery of …

Epigenetic mechanisms in neurological and neurodegenerative diseases

J Landgrave-Gómez, O Mercado-Gómez… - Frontiers in cellular …, 2015 - frontiersin.org
The role of epigenetic mechanisms in the function and homeostasis of the central nervous
system (CNS) and its regulation in diseases is one of the most interesting processes of …

Circular RNAs: the emerging class of non-coding RNAs and their potential role in human neurodegenerative diseases

L Kumar, Shamsuzzama, R Haque, T Baghel… - Molecular …, 2017 - Springer
The exciting world of research with RNAs has to its credit some breakthrough findings that
led to newer insights on multiple problems including that of human diseases. After the …

Neuronal dark matter: the emerging role of microRNAs in neurodegeneration

EF Goodall, PR Heath, O Bandmann, J Kirby… - Frontiers in cellular …, 2013 - frontiersin.org
MicroRNAs (miRNAs) are small, abundant RNA molecules that constitute part of the cell's
non-coding RNA “dark matter.” In recent years, the discovery of miRNAs has revolutionised …

[HTML][HTML] Inhibition of miR-34b and miR-34c enhances α-synuclein expression in Parkinson's disease

S Kabaria, DC Choi, AD Chaudhuri, MM Mouradian… - FEBS letters, 2015 - Elsevier
Mounting evidence suggests that microRNA (miR) dysregulation contributes to
neurodegenerative disorders including Parkinson's disease (PD). MiR-34b and miR-34c …

Genetics and epigenetics of Parkinson′ s disease

F Coppedè - The Scientific World Journal, 2012 - Wiley Online Library
In 1997 a mutation in the a-synuclein (SNCA) gene was associated with familial autosomal
dominant Parkinson's disease (PD). Since then, several loci (PARK1‐15) and genes have …

NeurimmiRs: microRNAs in the neuroimmune interface

H Soreq, Y Wolf - Trends in molecular medicine, 2011 - cell.com
Recent reports of microRNA (miR) modulators of both neuronal and immune processes
(here termed NeurimmiRs) predict therapeutic potential for manipulating NeurimmiR levels …