Type I and type II interferons (IFN) are central to both combating virus infection and
modulating the antiviral immune response. Indeed, an absence of either the receptor for type …

The current coronavirus disease (COVID‐19) pandemic caused by novel severe acute
respiratory syndrome coronavirus 2 (SARS‐CoV‐2) has a male bias in severity and …

Monocytes and cells of the dendritic cell lineage circulate in blood and eventually migrate
into tissue where they further mature and serve various functions, most notably in immune …

Plasmacytoid dendritic cells (pDCs) are specialized in rapid and massive secretion of type I
interferon (IFN-α/β) in response to foreign nucleic acids. Combined with their antigen …

Highlights•IFN-I signaling has recently been shown to contribute to viral immune
pathologies.•Elevated IFN-I signatures are found in persistent virus infections in multiple …

Human and mouse plasmacytoid dendritic cells have been shown to correspond to a
specialized cell population that produces large amounts of type I interferons in response to …

Persistent viral infections are a major health concern. One obstacle inhibiting the clearance
of persistent infections is functional inactivation of antiviral T cells. Although such …

Starting with multipotent progenitors, hematopoietic lineages are specified by lineage-
restricted transcription factors. The transcription factors that determine the decision between …

The developmental pathways that lead to the production of antigen-presenting dendritic
cells (DCs) are beginning to be understood. These are the last of the pathways of …

Toll-like receptors (TLRs) are best known for their ability to recognize microbial or viral
components and initiate innate immune responses. We showed here that TLRs and their …