The IL-36 family of cytokines includes three pro-inflammatory agonists (IL-36α, IL-36β, and
IL-36γ) and a receptor antagonist (IL-36Ra), which bind and signal through a heterodimeric …

Psoriasis is an immune-mediated inflammatory skin disease that involves mainly T helper
(Th) 17, Th1 and Th22 lymphocytes, which cause hyper-proliferation of the epidermis with …

Unmet needs in the treatment of psoriasis call for novel therapeutic strategies. Pustular
psoriasis and psoriatic arthritis often represent a therapeutic challenge. Focus on IL-36 …

IgE induced by type 2 immune responses in atopic dermatitis is implicated in the
progression of atopic dermatitis to other allergic diseases, including food allergies, allergic …

Interleukin (IL)-1 family cytokines initiate inflammatory responses, and shape innate and
adaptive immunity. They play important roles in host defense, but excessive immune …

Psoriasis and psoriatic arthritis, together known as psoriatic disease, is highly prevalent
chronic relapsing inflammatory disease affecting skin, joints or both and is associated with …

The IL-36 family belongs to a larger IL-1 superfamily and consists of three agonists (IL-
36α/β/γ), one antagonist (IL-36Ra), one cognate receptor (IL-36R) and one accessory …

Generalized pustular psoriasis (GPP) is a rare yet severe variant of psoriasis, characterized
by the eruption of superficial sterile pustules that appear suddenly and widely distributed …

Plaque psoriasis is an autoinflammatory and autoimmune skin disease, affecting 1-3% of the
population worldwide. Previously, high levels of IL-36 family cytokines were found in …

Interleukin (IL)-36 cytokines are members of the IL-1 superfamily, which consists of three
agonists (IL-36α, IL-36β and IL-36γ) and an IL-36 receptor antagonist (IL-36Ra). IL-36 …