Replication stress is a major cause of genomic instability and a crucial vulnerability of
cancer cells. This vulnerability can be therapeutically targeted by inhibiting kinases that …

Carbon-carbon coupling is the most important reaction in chemical, academia, and industrial
scales. The Suzuki-Miyaura coupling is a cross-coupling reaction in which the coupling …

For patients with non-small-cell lung cancer (NSCLC) tumors without currently targetable
molecular alterations, standard-of-care treatment is immunotherapy with anti-PD-(L) 1 …

Activation of the KRAS oncogene is a source of replication stress, but how this stress is
generated and how it is tolerated by cancer cells remain poorly understood. Here we show …

Highlights•Recent experience with targeted anticancer drugs and immunotherapies suggest
the traditional approach of using the maximal tolerated dose (MTD) is not ideal.•Project …

The quantum yield (QY) of a photocatalytic reaction significantly influences its performance,
as reactions with low QYs require more intense light sources and longer illumination times to …

DNA damage response (DDR) is critical to ensure genome stability, and defects in this
signaling pathway are highly associated with carcinogenesis and tumor progression …

Inhibitors of the DNA damage signaling kinase ATR increase tumor cell killing by
chemotherapies that target DNA replication forks but also kill rapidly proliferating immune …

Patients with small-cell lung cancer (SCLC) have poor prognosis and typically experience
only transient benefits from combined immune checkpoint blockade (ICB) and …

Purpose: Genomic instability is a hallmark of cancer and targeting DNA damage response
(DDR) is emerging as a promising therapeutic strategy in different solid tumors. The …