Fibrosis is characterized by the excessive extracellular matrix deposition due to
dysregulated wound and connective tissue repair response. Multiple organs can develop …

Diabetic nephropathy (DN) and diabetic retinopathy (DR) are microvascular complications of
diabetes. Microvascular endothelial cells are thought to be the major targets of …

Platelet-derived growth factors (PDGFs) and PDGF receptors (PDGFRs) are expressed in a
variety of tumors. Activation of the PDGF/PDGFR signaling pathway is associated with …

Importance Patients with advanced soft tissue sarcoma (STS) have a median overall survival
of less than 2 years. In a phase 2 study, an overall survival benefit in this population was …

The cellular environment where tumor cells reside is called the tumor microenvironment
(TME), which consists of borders, blood vessels, lymph vessels, extracellular matrix (ECM) …

Numerous cancers express platelet-derived growth factors (PDGFs) and PDGF receptors
(PDGFRs). By directly stimulating tumour cells in an autocrine manner or by stimulating …

Simple Summary Cancer is one of the hardest pathologies to fight, being one of the main
causes of death worldwide despite the constant development of novel therapeutic strategies …

Osteosarcoma (OS) is a highly malignant tumor occurring in bone tissue with a high
propensity to metastasize, and its underlying mechanisms remain largely elusive. The OS …

Vascular epidermal growth factor receptor-2 (VEGFR-2), as an important tyrosine
transmembrane protein, plays an important role in regulating endothelial cell proliferation …

Simple Summary Tumor growth in solid cancers requires adequate nutrient and oxygen
supply, provided by blood vessels created by angiogenesis. Numerous studies have …