Microfluidic cell sorting: a review of the advances in the separation of cells from debulking to rare cell isolation

CW Shields Iv, CD Reyes, GP López - Lab on a Chip, 2015 - pubs.rsc.org
Accurate and high throughput cell sorting is a critical enabling technology in molecular and
cellular biology, biotechnology, and medicine. While conventional methods can provide high …

The Poisson distribution and beyond: methods for microfluidic droplet production and single cell encapsulation

DJ Collins, A Neild, A DeMello, AQ Liu, Y Ai - Lab on a Chip, 2015 - pubs.rsc.org
There is a recognized and growing need for rapid and efficient cell assays, where the size of
microfluidic devices lend themselves to the manipulation of cellular populations down to the …

Surface acoustic wave microfluidics

X Ding, P Li, SCS Lin, ZS Stratton, N Nama, F Guo… - Lab on a Chip, 2013 - pubs.rsc.org
The recent introduction of surface acoustic wave (SAW) technology onto lab-on-a-chip
platforms has opened a new frontier in microfluidics. The advantages provided by such SAW …

Droplet-based microfluidics in drug discovery, transcriptomics and high-throughput molecular genetics

N Shembekar, C Chaipan, R Utharala, CA Merten - Lab on a Chip, 2016 - pubs.rsc.org
Droplet-based microfluidics enables assays to be carried out at very high throughput (up to
thousands of samples per second) and enables researchers to work with very limited …

Engineers are from PDMS-land, Biologists are from Polystyrenia

E Berthier, EWK Young, D Beebe - Lab on a Chip, 2012 - pubs.rsc.org
As the integration of microfluidics into cell biology research proceeds at an ever-increasing
pace, a critical question for those working at the interface of both disciplines is which device …

Monolithic microfabricated valves and pumps by multilayer soft lithography

MA Unger, HP Chou, T Thorsen, A Scherer, SR Quake - science, 2000 - science.org
Soft lithography is an alternative to silicon-based micromachining that uses replica molding
of nontraditional elastomeric materials to fabricate stamps and microfluidic channels. We …

Isolation of rare circulating tumour cells in cancer patients by microchip technology

S Nagrath, LV Sequist, S Maheswaran, DW Bell… - Nature, 2007 - nature.com
Viable tumour-derived epithelial cells (circulating tumour cells or CTCs) have been identified
in peripheral blood from cancer patients and are probably the origin of intractable metastatic …

Advances in technical assessment of spiral inertial microfluidic devices toward bioparticle separation and profiling: A critical review

M Bagi, F Amjad, SM Ghoreishian… - BioChip Journal, 2024 - Springer
Separation of micro-and nano-sized bioparticles is essential for efficient diagnostics,
chemical and biological analyses, drug development, food and chemical processing, and …

Poly (dimethylsiloxane) as a material for fabricating microfluidic devices

JC McDonald, GM Whitesides - Accounts of chemical research, 2002 - ACS Publications
This Account summarizes techniques for fabrication and applications in biomedicine of
microfluidic devices fabricated in poly (dimethylsiloxane)(PDMS). The methods and …

Physics and applications of microfluidics in biology

DJ Beebe, GA Mensing… - Annual review of …, 2002 - annualreviews.org
▪ Abstract Fluid flow at the microscale exhibits unique phenomena that can be leveraged to
fabricate devices and components capable of performing functions useful for biological …