Switching on cilia: transcriptional networks regulating ciliogenesis
Cilia play many essential roles in fluid transport and cellular locomotion, and as sensory
hubs for a variety of signal transduction pathways. Despite having a conserved basic …
hubs for a variety of signal transduction pathways. Despite having a conserved basic …
Food sensitizes C. elegans avoidance behaviours through acute dopamine signalling
Many behavioural states are modulated by food availability and nutritional status. Here, we
report that in Caenorhabditis elegans, the presence of an external food source enhances …
report that in Caenorhabditis elegans, the presence of an external food source enhances …
Characterization of the human RFX transcription factor family by regulatory and target gene analysis
D Sugiaman-Trapman, M Vitezic, EM Jouhilahti… - BMC genomics, 2018 - Springer
Background Evolutionarily conserved RFX transcription factors (TFs) regulate their target
genes through a DNA sequence motif called the X-box. Thereby they regulate cellular …
genes through a DNA sequence motif called the X-box. Thereby they regulate cellular …
[HTML][HTML] Transcriptional profiling of C. elegans DAF-19 uncovers a ciliary base-associated protein and a CDK/CCRK/LF2p-related kinase required for intraflagellar …
Cilia are ubiquitous cell surface projections that mediate various sensory-and motility-based
processes and are implicated in a growing number of multi-organ genetic disorders termed …
processes and are implicated in a growing number of multi-organ genetic disorders termed …
Functional specialization of sensory cilia by an RFX transcription factor isoform
In animals, RFX transcription factors govern ciliogenesis by binding to an X-box motif in the
promoters of ciliogenic genes. In Caenorhabditis elegans, the sole RFX transcription factor …
promoters of ciliogenic genes. In Caenorhabditis elegans, the sole RFX transcription factor …
[HTML][HTML] The in vivo dissection of direct RFX-target gene promoters in C. elegans reveals a novel cis-regulatory element, the C-box
J Burghoorn, BP Piasecki, F Crona, P Phirke… - Developmental …, 2012 - Elsevier
At the core of the primary transcriptional network regulating ciliary gene expression in
Caenorhabditis elegans sensory neurons is the RFX/DAF-19 transcription factor, which …
Caenorhabditis elegans sensory neurons is the RFX/DAF-19 transcription factor, which …
Femtosecond laser ablation reveals antagonistic sensory and neuroendocrine signaling that underlie C. elegans behavior and development
The specific roles of neuronal subcellular components in behavior and development remain
largely unknown, even though advances in molecular biology and conventional whole-cell …
largely unknown, even though advances in molecular biology and conventional whole-cell …
An expanded role for the RFX transcription factor DAF-19, with dual functions in ciliated and nonciliated neurons
Abstract Regulatory Factor X (RFX) transcription factors (TFs) are best known for activating
genes required for ciliogenesis in both vertebrates and invertebrates. In humans, eight RFX …
genes required for ciliogenesis in both vertebrates and invertebrates. In humans, eight RFX …
Accelerating gene discovery by phenotyping whole-genome sequenced multi-mutation strains and using the sequence kernel association test (SKAT)
Forward genetic screens represent powerful, unbiased approaches to uncover novel
components in any biological process. Such screens suffer from a major bottleneck …
components in any biological process. Such screens suffer from a major bottleneck …
The First Report of a Missense Variant in RFX2 Causing Non-Syndromic Tooth Agenesis in a Consanguineous Pakistani Family
Background: The syndromic and non-syndromic congenital missing teeth phenotype is
termed tooth agenesis. Since tooth agenesis is a heterogeneous disorder hence, the …
termed tooth agenesis. Since tooth agenesis is a heterogeneous disorder hence, the …