Bone remodeling is tightly controlled by osteoclast-mediated bone resorption and osteoblast-
mediated bone formation. Fine tuning of the osteoclast–osteoblast balance results in strict …

Osteomyelitis, or inflammation of bone, is most commonly caused by invasion of bacterial
pathogens into the skeleton. Bacterial osteomyelitis is notoriously difficult to treat, in part …

Abstract Purpose of Review To describe in detail the clinical synopsis and pathophysiology
of chronic non-bacterial osteomyelitis and SAPHO syndrome. Recent Findings Chronic non …

Chronic non-bacterial osteomyelitis (CNO) is a rare auto-inflammatory bone disorder, with a
prevalence of around one in a million patients. In the more severe form, it is referred to as …

Chronic nonbacterial osteomyelitis (CNO) can cause significant morbidity, including bone
pain and damage. In the absence of clinical trials, treatments include non-steroidal anti …

Majeed syndrome is a multi-system inflammatory disorder affecting humans that presents
with chronic multifocal osteomyelitis, congenital dyserythropoietic anemia, with or without a …

Chronic recurrent multifocal osteomyelitis: diagnosis and tr... : Current Opinion in Pediatrics
Chronic recurrent multifocal osteomyelitis: diagnosis and treatment : Current Opinion in …

Monogenic autoinflammatory disorders are a group of conditions defined by systemic or
localized inflammation without identifiable causes, such as infection. In contrast to classical …

Proline-serine-threonine-phosphatase-interacting protein 2 (PSTPIP2) belongs to the
Fes/CIP4 homology-Bin/Amphiphysin/Rvs (F-BAR) domain family. It exhibits lipid-binding …

Chronic recurrent and multifocal osteomyelitis (CRMO) is a nonsporadic autoinflammatory
disorder. Currently, it is diagnosed based on clinical, radiologic, pathological, and …