Metabolic rewiring and epigenetic remodeling, which are closely linked and reciprocally
regulate each other, are among the well-known cancer hallmarks. Recent evidence …

The term epigenetics is defined as heritable changes in gene expression that are not due to
alterations of the DNA sequence. In the last years, it has become more and more evident …

Polycomb proteins form chromatin-modifying complexes that implement transcriptional
silencing in higher eukaryotes. Hundreds of genes are silenced by Polycomb proteins …

The establishment and maintenance of epigenetic gene silencing is fundamental to cell
determination and function. The essential epigenetic systems involved in heritable …

Polycomb group proteins are essential for early development in metazoans, but their
contributions to human development are not well understood. We have mapped the …

Chromatin alterations have been associated with all stages of tumour formation and
progression. The best characterized are epigenetically mediated transcriptional-silencing …

The Polycomb group (PcG) proteins form chromatin-modifying complexes that are essential
for embryonic development and stem cell renewal and are commonly deregulated in cancer …

Polycomb group (PcG) proteins are epigenetic gene silencers that are implicated in
neoplastic development. Their oncogenic function might be associated with their well …

The p16INK4A and p14ARF proteins, encoded by the INK4A-ARF locus, are key regulators
of cellular senescence, yet the mechanisms triggering their up-regulation are not well …

Polycomb-repressive complex 2 (PRC2)-mediated histone methylation plays an important
role in aberrant cancer gene silencing and is a potential target for cancer therapy. Here we …