The discovery of RNA interference (RNAi) as a naturally occurring mechanism for gene
knockdown has attracted considerable attention toward the use of small interfering RNAs …

The Akt/mechanistic target of rapamycin (mTOR) signaling pathway governs macromolecule
synthesis, cell growth, and metabolism in response to nutrients and growth factors …

Aims Either insufficient or excessive autophagy causes cellular death and contributes to
myocardial ischaemia/reperfusion (I/R) injury. However, mechanisms controlling the 'right …

Activating transcription factor 3 (ATF3) is a stress-induced transcription factor that has been
shown to repress inflammatory gene expression in multiple cell types and diseases …

The nonselective β-adrenergic receptor antagonist (β-blocker) carvedilol has been shown to
protect against myocardial injury, but the detailed underlying mechanisms are unclear. We …

Regulated in development and DNA damage-response 1 (REDD1) is a stress-induced
protein that controls various cellular functions, including metabolism, oxidative stress …

Disruption of peripheral circadian rhyme pathways dominantly leads to metabolic disorders.
Studies on circadian rhythm proteins in the heart indicated a role for Clock or Per2 in cardiac …

Ischemic stroke (IS) is one of the leading causes of disability and death worldwide. Long-
chain fatty-acid-coenzyme A ligase 4 (ACSL4) is a critical isozyme for ferroptosis that …

Timely reperfusion in acute myocardial infarction has improved clinical outcomes but the
benefits are partially offset by ischemia-reperfusion injury (I/R). MiRNA regulates mRNA of …

Cadmium, a highly ubiquitous toxic heavy metal, has been widely recognized as an
environmental and industrial pollutant, which confers serious threats to human health. The …