The acetylation of histone and non-histone proteins has been implicated in several disease
states. Modulation of such epigenetic modifications has therefore made histone …

Epigenetic modifications are emerging as major players in the pathogenesis of
neurodegenerative disorders and susceptibility to acute brain injury. DNA and histone …

Dietary polyunsaturated fatty acids (PUFA) are increasingly recognized for their health
benefits, whereas a high production of endogenous fatty acids–a process called de novo …

Understanding the contribution of imbalance in protein acetylation levels and dysfunction of
transcription to neurodegenerative diseases provides the rationale for the use of epigenetic …

Neuroepigenetics, a new branch of epigenetics, plays an important role in the regulation of
gene expression. Neuroepigenetics is associated with holistic neuronal function and helps …

Background: Huntington's disease (HD) is a genetic neurodegenerative disease caused by
trinucleotide repeat (CAG) expansions in the human HTT gene encoding the huntingtin …

Huntington's disease (HD) is a progressive neurological disorder for which there are no
disease-modifying treatments. Although, the exact underlying mechanism (s) leading to the …

Abstract Spinocerebellar ataxia type 17 (SCA17) is caused by CAG/CAA repeat expansion
on the gene encoding a general transcription factor, TATA-box-binding protein (TBP). The …

Parkinson's disease (PD) is characterized by slow, progressive degeneration of
dopaminergic neurons in the substantia nigra. The cause of neuronal death in PD is largely …

Histone deacetylase 3 (HDAC3), a member of the Class I subfamily of HDACs, is found in
both the nucleus and the cytoplasm. Its roles in the nucleus have been well characterized …